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However, GSH depletion is a most characteristic finding when red blood cells are subjected to oxidative challenge, and in one careful study it has been demonstrated that during an attack of favism, the first measurable biochemical change is a decrease in NADPH, followed by a decrease in GSH, in keeping with stages 1 and 2 described earlier

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Epithalon Research in Aged Rhesus Monkeys Non-human-primate findings are more biologically relevant than rodent results but remain preclinical