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Ryu et al showed that chrysin might exert anti-proliferative and pro-apoptotic effects on human endometriosis cells by regulating endoplasmic reticulum stress and the PI3K/Akt signaling pathways

Activation of stress-responsive TDO or immune-responsive IDO can limit the availability of tryptophan for serotonin synthesis and increase the downstream production of neurotoxic or neuroprotective metabolites (31)

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For example, a DNA repair protein, redox factor Ref-1, was reported to promote the DNA-binding activities of several transcription factors, including HIF-1 and p53, which confers cytoprotective function under hypoxia