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doi:10.1016/0014-5793(90)80922-6

An Innovator company in order to develop a new drug spends a big amount of money on its R&D and then has to get its product pass certain Clinical and Non-Clinical tests and studies

Several studies have shown that regular physical activity increases endothelial vasodilation in people who have high blood pressure and heart disease, as well as in healthy individuals (52, Studies have also shown that exercise increases antioxidant activity, which helps inhibit the breakdown of nitric oxide caused by free radicals ( The benefits of exercise on endothelial health and nitric oxide production can be seen in as little as 10 weeks when exercising for 30 minutes at least three times a week (52)

Eidson LN, Murphy AZ (2019) Inflammatory mediators of opioid tolerance: implications for dependency and addiction