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This effect is achieved through the activation of signaling pathways such as the ERK1/2, PI3K/AKT, and cAMP/PKA/-cat-Ser675 pathways, which are mediated by GLP-1RAs

MGE: data curation, formal analysis, software, validation, visualization, writing original draft, and writing review and editing

While OACs remain essential for stroke prevention in AF patients, these findings suggest that the benefit of stroke prevention must be weighed against the risk of increased long-term disability following AIS

Curcumin itself has been shown to offer neuroprotection in cerebral ischemia through various mechanisms, including anti-oxidation, anti-inflammation, anti-apoptosis, and protection of the blood-brain barrier, making this combined strategy particularly compelling (547)