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After baseline assessments and dosing, urine specimens were collected from participants

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The circuits involved in addiction are the: amygdala and hippocampus affected by fear, nucleus accumbens and the ventral pallidum which respond to rewards that increase dopamine, anterior cingulate gyrus and prefrontal cortex, responsible for cognitive control, downregulate control of the orbito-frontal cortex, and Orbito-frontal cortex evaluates the value of rewards and the decision to use a substance is given