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Under the stimulation of high mechanical stress, activation of the PIEZO1 protein leads to a decrease in the intracellular GSH level of chondrocytes, a reduction in the function and expression of GPX4, and a significant increase in the intracellular calcium ion concentration, ultimately inducing ferroptosis of chondrocytes

doi: 10.3390/cells12081187 140 EslahiAVOlfatifarMZakiLKarimipour SaryazdiABarikbinFMalekiAet al