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Khatri N, Sumadhura B, Kumar S, Kaundal RK, Sharma S, Datusalia AK

Asthenic and atrophic changes are accumulating with aging 133 , thus reducing neuroprotection and lowering brain resilience and therefore increasing the susceptibility to age-dependent neurodegenerative disorders

lethal molecules were compared in a ten-point, two-fold dilution series modulatory profiling assay (high dose of dilution series in brackets): erastin (20 M), RSL3 (5 M), hydrogen peroxide (H 2 O 2 , 5 mM), artesunate (200 M), phenylarsine oxide (PAO, 1 M), taxol (0.5 M), suberoylanilide hydroxamic acid (SAHA, 50 M), trichostatin A (2.5 M), doxorubicin (2 M), fenretinide (50 M), staurosporine (STS, 0.5 M), brefeldin A (10 M), -lapachone (25 M), bortezomib (5 M), carbonyl cyanide m-chlorophenyl hydrazine (CCCP, 50 M), 2-methoxyestradio ShRNA screening and follow-up studies identified 51 initial candidate suppressor genes, each represented by 2 hairpins common to both cell lines

World J Biol Psychiatry 18(3):162214 Tseilikman VE et al (2024) Resveratrol: a multifaceted guardian against anxiety and stress disordersan overview of experimental evidence