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Advances in high-resolution technologies such as single-cell omics, spatial metabolomics, and imaging mass spectrometry have progressively unveiled the metabolic heterogeneity landscape within CRC [130, 131]

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[58] published the findings of their follow up study in 89 patients with ulcerative colitis who were thiopurine nave and had achieved remission with either steroids or infliximab, and were randomised to receive first-line azathioprine monotherapy or a combination of low dose azathioprine and allopurinol