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SAH is then hydrolyzed to homocysteine

Many in vitro (Reference Cruzat, Keane and Scheinpflug12) , and in vivo experiments (Reference Moura, Lollo and Morato42) , including animal models submitted to exhaustive exercise training (Reference Petry, Cruzat and Heck33,Reference Petry, Cruzat and Heck34) have identified the important role of glutamine availability/metabolism and the anti-inflammatory response mediated by HSPs

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Half-life is influenced by drug distribution, drug metabolism, and drug excretion, each of which can be influenced by many factors such as age, use of concurrent medications, and presence of liver or renal disease