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These mutations, which primarily occur at C228T and C250T, create novel Ets/TCF binding sites, leading to aberrant TERT expression and sustained telomerase activity

First, we provide a general introduction to glutathione metabolism in relation to its antioxidant role and oxidative stress

Functional assessment in rats Body weights Each animal was weighed on days 7, 5, and 1 before the dosing phase started, and on days 4, 7, 11, and 14 during the dosing phase and the recovery phase

These findings emphasize the critical need for early intervention, personalized treatment strategies, and ongoing research into the disorder's pathophysiology and long-term management (Grande et al., 2016