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They can - and heres how: its likely you wont wait for your filler to entirely break down before you come back in, so when we inject filler on top of filler, and especially when that filler is placed in the same area, then the actual HA molecules should have less surface-area-contact with your tissues, which in studies has been shown to allow them to be more resistant to breaking down - making them last longer

This is beneficial for athletes, fitness enthusiasts, or anyone with physically demanding routines

doi: 10.1128/mcb.24.20.9079-9091.2004

Studies show it can counteract both NO-synthase inhibition (L-NAME) and NO-synthase overstimulation (L-arginine)