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Key areas of this immune communication between the brain and the periphery include the neurovascular unit, the brainstem and circumventricular organs of the brain as well as the vagus nerve (DiSabato et al., 2016)

The sequence of reactions may be formulated as follows: (6) Enz-[Por-Fe(III)] + nH 2 O 2 = Enz-[Por+.-Fe(IV)=O] + H 2 O + (n-1)H 2 O 2 (7) Enz-[Por+.-Fe(IV)=O] + (n-1)H 2 O 2 = Enz-[Por-Fe(III)] + H 2 O + O 2 + (n-2)H 2 O + (n-2/2)O 2 Adding Equations 6 and 7 gives: (8) nH 2 O 2 = 2H 2 O + O 2 + (n-2)H 2 O + (n-2/2)O 2 Which simplifies to: (9) nH 2 O 2 = nH 2 O + n/2 O 2 Finally, doubling both sides of Equation 9 and dividing through by n, gives Equation 1: (1) 2H 2 O 2 = 2H 2 O + O 2 By these reactions effectively reducing back to Equation 1, it implies this preliminary network hypothesis presented here does not contradict the known catalase H 2 O 2 disproportionation chemistry that has previously been discovered and investigated

1 This can impact one at any age but is more common in older age individuals being 60 years and older