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Recent studies have shown that AMPK in cells can directly phosphorylate five conserved serine residues in folliculin interacting protein 1 (FNIP1), inhibiting the function of the folliculin (FLCN)-FNIP1 complex to promote transcription factor EB (TFEB) nuclear translocation, thereby inducing mitochondrial biogenesis (Figure 5)

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However, the methodology used is primarily based on the Stokes radius of the analyzed (fusion) protein

16,17 But regardless of the trigger, dry eyes ultimately result from a simple imbalance: too little production of tears, or too rapid evaporation of tears on the surface of the eye