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doi: 10.1016/j.pnpbp.2022.110702 27 JiaoH.YangH.YanZ.ChenJ.XuM.JiangY.et al

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The observed decreased expression of the enzyme HPRT1 , which converts hypoxanthine to IMP, provides both a mechanistic explanation for the observed increased abundance of xanthines in PD and is associated with a shortage of cellular ATP as a further pathological downstream effect (see Fig