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Interestingly, orthotopic injection of an SYN-encoding AAV into the SN only induced neurodegeneration in the presence of Fc gamma receptors (191), which implies an antibody-dependent activation of the complement cascade and/or antibody-dependent cellular cytotoxicity that may be mediated by microglia, for example (192)

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Eur J Biochem 47(3):469474 Mats JM, Prez-Gmez C, De Castro IN (1999) Antioxidant enzymes and human diseases

Suzuki A, Xiao L, Hayashi Y, Blum MA, Welsh JW, Lin SH, Lee JH, Bhutani MS, Weston B, Maru DM, Rice DC, Swisher SG , Hofstetter WL, Erasmus J, Ajani JA