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In contrast, Gram-positive bacteria activate macrophages through cell wall components such as peptidoglycan and teichoic acid, which bind to TLR2, resulting in a comparatively weaker immune response (Elson et al, 2007

3 The disease therefore represents a great financial burden on health care systems in terms of secondary care for fractures and long-term primary and social care, with current estimated costs to the NHS being 5m per day