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first proposed the concept of oxidative stress, either caused by an increase in free radical production or a reduction in the scavenging capacity of the body, leading to disorders in the oxidation and antioxidant systems, resulting in oxidative damage by free radical accumulation (Sohal and Allen, 1990)

Identification results of potential biomarkers in nucleus pulposus cells

IGF-1 DES, also known as insulin-like growth factor 1 DES , is a truncated version (splice variant) of IGF-1, a hormone produced by the human liver

It has become a promising neuroprotective agent not only in PD and AD but also in other neurodegenerative diseases, including ALS, stroke and MS (Fig