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When artesunate and chloroquine are combined, they can regulate macrophages, inhibit the proliferation of colon cancer (HCT 116 and CT26) cells, and reverse the immunosuppressive tumor microenvironment [176]

NFE2L2 plays a pivotal role in regulating antioxidant genes involved in both GPX4-dependent (e.g., GPX4 and SLC7A11) and GPX4 independent pathways (e.g., AIFM2 and MT1G [metallothionein 1G]) [34, 83, 156]

However, further studies are necessary to determine whether NRDE2 deficiency could be used as a biomarker for PARP-1 inhibitor response in other cancer types or if the loss of other genes may have an impact comparable to that of NRDE2 (158)

Currently, recommended anti-tuberculosis drugs include isoniazid, rifampicin, ethambutol, and pyrazinamide