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In neurodegenerative diseases, microglia-derived lactate enhances pro-inflammatory cytokine release (e.g., TNF-, IL-6 and IL-1) (Yang et al

10.1016/j.bmcl.2016.12.063 186 SloanJ

Kayser MA

2022), while the PPAR agonist bezafibrate upregulates PGC-1 to stimulate mitochondrial biogenesis, jointly improving MRC functional efficiency (Costa et al