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Exposure to chronic or repeated stress leads to the release of adrenal steroids that affect the shape and structure of neurons, particularly in the hippocampus, a region essential for memory and emotion (97)

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First, a systematic search was conducted in PubMed, Web of Science, and Embase from inception to March 2026 using combinations of tinnitus AND (neurodegenerative diseases OR Alzheimer disease OR Parkinson disease) AND (treatment OR therapy OR intervention), supplemented with mechanism-specific terms paired with tinnitus (e.g., neuroinflammation, oxidative stress, BDNF, NMDA receptor, epigenetic)