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GLP-1 medications have substantially more long-term safety data, particularly for semaglutide which has been in widespread clinical use for over a decade across multiple indications

(With steroid-induced osteoporosis, your bones become thin and weak from using certain corticosteroids.) In clinical trials, 3.6% of adults taking Prolia for steroid-induced osteoporosis had headaches

Across those trials, AOD-9604 demonstrated a strong safety profile adverse events were comparable to placebo, no genotoxicity was found, and it showed no negative effect on glucose or insulin sensitivity

Injection Timing No definitive evidence establishes optimal injection timing