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Though LA has long been touted as an antioxidant, it has also been shown to improve glucose and ascorbate handling, increase eNOS activity, activate Phase II detoxification via the transcription factor Nrf2, and lower expression of MMP-9 and VCAM-1 through repression of NF-kappa-B

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As for the skin benefits of Zanthoxylum Piperitum, it might have antioxidant effects (with active components called hyperoside and quercitrin ), but more importantly, it is an antibacterial and natural preservative agent