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Wang and Han, 2019)

These individuals may experience various complications, such as cardiovascular disease (including type 2 diabetes, hypertension, and hyperlipidemia), metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic syndrome (MS), and endometrial cancer (EC) (Rena and Lang, 2018)

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Meanwhile, it has also been indicated that iron-loaded cells transfer intracellular ferritin to CD63 + EVs for secretion via nuclear receptor coactivator 4 (NCOA4) [161]