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Acknowledgments The authors would like to acknowledge the support of Rika Kakutani (Division of Orthopedic Surgery, Niigata University) in collecting and reviewing the reference articles and drawing Figure 1, and Akiko Yoshi (Department of Neurosurgery, Brain Research Institute, Niigata University) for providing exclusive support with the experiments

Nonetheless, high-fat diets may negatively impact skeletal health by promoting the gut microbial transformation of dietary L-carnitine into TMAO (166), so disrupting L-carnitines advantageous effects and eventually influencing BMD

Propyl gallate plays a nephroprotective role in early stage of diabetic nephropathy associated with suppression of glomerular endothelial cell proliferation and angiogenesis