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However, there have been indications that regular doses of 1 g over extended periods, such as months or years, may reduce bactericidal activity in leukocytes and increase the risk of stone formation caused by temporary urate excretion elevation

Molecular and Cellular Physiology of Renal Organic Cation and Anion Transport

Importantly, BRs exhibit physiological activity at concentrations approximately 1000 times lower than other plant hormones

ART-induced mitochondrial toxicity with increased lactate to compete with uric acid excretion by the renal tubules and increased cell turnover followed by increased degradation of nucleotides accompanied by elevated uric acid in the serum were some of the possibilities by which uric acid is elevated in people living with HIV on HAART (6669)