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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

It introduces variables that confound interpretation entirely

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A serum B12 level between 300 pg/mL and 900 pg/mL is considered normal and levels above 900 pg/mL are considered high