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As expected, c-MET927-LZ forms a dimer on its own and can bind to HGF in a similar manner as c-MET927 (Supplementary Fig

Monitor creatinine clearance before each dose (2.7, 5.3) Osteonecrosis of the Jaw (ONJ) has been reported

Treatment may include CBT-I, sleep schedule support, mental health care, medication review, sleep apnea screening, circadian rhythm interventions, or other individualized options