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Cells depleted of Erv1 exhibit a more reduced Mia40 redox state, but also in these cells the additional deletion of GLR1 did not affect the Mia40 redox state (Figure 8C)

(2) molecular dynamics simulated annealing restraining FOXO4 FH (without flexible regions) harmonically to its template structure (using a non-crystallographic force constant of 10,000 kcal mol 1 2 ), with additional dihedral angle restraints from 1 H, 15 N, and 13 C chemical shifts using TALOS-N 56 , hydrogen bond restraints (region p53 residues 48-55

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