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Iron restriction prevents diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rat

2 MASLD is primarily characterized by abnormal lipid accumulation in hepatocytes, typically presenting as simple steatosis

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Accumulated p53 is stabilized and activated through posttranslational modifications, including methylation, phosphorylation and acetylation, 53 which regulate gene transcription and affect a series of signaling pathways involved in apoptosis, cell cycle arrest, senescence, autophagy, ferroptosis, cellular metabolism and the tumor immune microenvironment (TME) 54,55,56 (Fig