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This positive feedback loop reinforces metabolic symbiosis between cancer cells and other components of the TME

Saunders et al., 1993

Freezing is equally damaging and immediately renders the medication unusable

Ferroptosis and pyroptosis Cellular pyroptosis, mediated by caspases, is an inflammatory type of programmed cell death marked by membrane disruption and the release of pro-inflammatory cytokines, which amplifies local inflammation [128]