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L-type amino acid transporter 1 (LAT1)-utilizing efflux transporter inhibitors can improve the brain uptake and apoptosis-inducing effects of vinblastine in cancer cells

Oral administration may benefit from fasted dosing based on general peptide absorption principles, but consistency same timing daily matters more than the absolute relationship to meals

The targeting vector included homology arms (4.97 kb and 1.83 kb) generated by PCR from C57Bl/6 N BAC DNA, as well as Cre-ERT2 and -globin poly(A) sequences assembled via overlap-extension PCR