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While not entirely comprehensive and lacking robust evidence, this hypothesis has spurred significant research in the field

doi: 10.1016/j.cmet.2011.08.016 30 LoveSMinersJS

Cell 115:787798 Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Acetyl-CoA carboxylase 1 (ACC1) associates key energy metabolism with lipogenesis and is a rate-limiting enzyme involved in de novo lipogenesis through the carboxylation of acetyl-CoA ( de novo synthesized fatty acids are incorporated into phospholipids or localized to lipid rafts to be implicated in membrane-related activities, and some are stored in the form of lipid droplets to buffer excess lipids