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In MRL/lpr mice, altered microbiome composition was associated with increased intestinal permeability, evidenced by increased fecal albumin and IgA levels ( Figures 6A, B ) and decreased gut tight junction protein ZO-2 ( Figure 6D )

doi: 10.1038/hr.2008.27 17 FarkasELuitenPG

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Results: GHK-Cu alleviated weight loss, improved the disease activity index (DAI), reduced colonic edema and shortening, attenuated inflammatory damage, increased goblet cell numbers, suppressed inflammatory cytokines such as TNF-, IL-6, and IL-1, and promoted mucosal repair