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The use of these diurnal ex vivo animal models has shown that UV-A radiation has the potential to be more harmful than UV-B radiation, possibly due to the absorption of this longer wavelength energy in deeper lens cell layers that inactivates enzymatic activity involved in the protection against oxidative stress

Although not extensively studied, these findings suggest that the gut microbiota may influence NOferroptosis crosstalk through metabolic pathways, warranting further investigation

However, in addition to the above biological indicators, there are still basic criteria to demonstrate the involvement of ferroptosis, which should be inhibited by lipophilic antioxidants (e.g., ferrostatin-1 and lipstatin-1)

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