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Drug resistance can occur due to genetically unstable human cancer cells, and drug-resistant features can either present before treatment (intrinsic) or develop after therapy (acquired)

Acquired resistance and antibody response of raccoons ( Procyon lotor ) to sequential feedings of Ixodes scapularis (Acari: Ixodidae)

And cyano COBAL amine (COBAL being short for the metal cobalt) doesn't sound so great either