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Being an antioxidant, they help protect cells from damage caused by free radicals, which can contribute to aging and other diseases

the metabolically stabilized 6-AH family member, D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 had a t 1/2 in blood of 80 min compared to the parent compound Norleual (Nle-Tyr-Leu- -(CH 2 NH 2 ) 3-4 -His-Pro-Phe, SEQ ID NO: 1), which had a t 1/2 in blood of 5 min

Cluster biogenesis also demands electrons, provided by ferredoxin 2 (FDX2), and is allosterically activated by frataxin (FXN)

Lowering the expression of GDF11 in the adult hippocampus, using a Cre-inducible Gdf11 deletion mouse, increases the number of neural stem/progenitor cells [58] confirming that endogenous GDF11 acts locally in the brain and acts as a negative regulator of neurogenesis even in adult mice