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If HCPCS codes are added to an APC and, after recalibrating its relative payment weight, holding its unadjusted copayment amount constant results in an increase in the coinsurance percentage for the reconfigured APC, the copayment amount would be calculated as the product of the payment rate of the reconfigured APC and the lowest coinsurance percentage of the codes being added to the reconfigured APC

[] This metabolic crisis prompts the opening of the mitochondrial permeability transition pore, leading to the collapse of the membrane potential, organelle swelling, and, ultimately, programmed cell death

They are unapproved compounded products, prepared by compounding pharmacies, which have not been reviewed by the FDA for safety, efficacy or quality in this indication

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