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Is it possible that these pathophysiological mechanisms are more prominent in 2D-cultures due to the lack of cell-cell communication

Plant Cell Physiol 52(11):19311940 Arregui G, Hiplito P, Pallol B, Lara-Dampier V, Garca-Rodrguez D, Varela HP, Tavakoli Zaniani P, Balomenos D, Paape T, Coba de la Pea T, Lucas MM (2021) Mercury-tolerant Ensifer medicae strains display high mercuric reductase activity and a protective effect on nitrogen fixation in Medicago truncatula nodules under mercury stress