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oral Time (hours) Bioavailability (F) Can be used to define how well a drug is absorbed and reaches its site of action Usually determined by comparison of oral and IV absorption F= amount of drug absorbed in systemic circulatio n following oral administra tion amount of drug absorbed when the same dose is administer ed intravenou sly Measuring the drug in the plasma Half-life (T0.5 ) The time for the plasma drug concentration to fall to half its original value Clearance rate of eliminatio n clearance = plasma drug concentration Removal of drug from plasma First order kinetics Most drugs are eliminated with first order kinetics

Additionally, one study indicated that the accumulation of autophagic substrates and impaired autophagic flux independently signify suppressed autophagy post-TBI (Sarkar et al., 2014)

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