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Nevertheless, relative glutamatergic excess appears to be specific to early stages of illness [8], and relates to more severe symptoms at presentation [17], as well as gray matter decline [19], cognitive [20], and functional [16, 17] impairments

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Several studies have proven the anti-inflammatory potential of NTZ as it downregulates proinflammatory cytokines in LPS-induced systemic inflammation (Vanessa Legry et al., 2022), ovariectomized mice (Li et al., 2021), and type-2 diabetic patients (Castillo-Salazar et al., 2021) which supports our findings