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More surprisingly, we observed positive gene enrichment in DNA replication fork collapse-responsive genes (RAD51D, SAMHD1, and ZRANB3) 53,54 , oxidative DNA damage repair genes (OGG1, MGMT) 55 , and several antioxidant genes (CAT, GPX7, PRDX3, and SOD2) 56 between day 15 and day 20 of differentiation in BWS hepatocytes (Supplementary Fig