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Golden Retrievers show higher taurine deficiency rates overall Large and giant breeds need more dietary taurine Some grain-free diets may lower taurine absorption Senior dogs process amino acids less efficiently Dogs with existing heart conditions often benefit most Lamb-based or restricted diets sometimes reduce taurine levels Vet bloodwork confirms deficiency before starting any supplement The safest move is a blood test

Thus, in order to be able to distinguish ASM-mediated antiviral effects from these off-target mechanisms, the future trials should (i) firstly pre-specify the target engagement (ASM activity and ceramide/SM indices in plasma/EVs) and then test whether biomarker shifts will correlate with virologic/clinical endpoints, (ii) Secondly, these should evaluate pharmacokineticpharmacodynamic exposuretarget engagement relationships in the relevant disease stage and (iii) then whenever possible should use mechanism-separating comparators (such as class-matched non-FIASMs or FIASMs with divergent non-ASM pharmacology but having similar ASM inhibition strength)