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BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

Also, an increase in mitochondrial Ca 2+ may by upregulation pyruvate dehydrogenase and increasing the potential of the mitochondrial membrane, stimulate oxidative metabolism

Upon evaluation of peripheral smear and biochemical tests, a non-immune hemolytic component was also identified with deficient Vit B12 levels in case 1 and highly elevated levels post-supplementation in case 2