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We note that the applicant's inclusion/exclusion criteria and reasoning for the third analysis are unclear

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YangWWangYFuCLiCFengFLiHet alQuantitative visualization of myocardial ischemia-reperfusion-induced cardiac lesions via ferroptosis magnetic particle imaging

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In addition, a glycine residue located four amino acids upstream (three residues in GSTLs) the N-cap residue (S/T) is also well-conserved in GSTs and is likely essential for folding by stabilizing the GXXh(S/T)XXDh conserved loop-helix substructure (Kong et al., 2003) demonstrating the importance of these motifs both for protein folding and stability

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