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Hepatic PGC-1 overexpression increases APAP-induced ROS accumulation due to altered glutathione metabolism Lipid accumulation per se has been often associated with an increased ROS content

Interestingly, the activity of methylating enzymes such as the S -adenosylmethionine-dependent protein arginine methyltransferase (type I) 103 responsible for the ADMA synthesis or the activity of ADMA hydrolyzing enzymes such as dimethylarginine dimethylaminohydrolase 102 are redox sensitive

Nature communications , 11 (1), 5205

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