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Furthermore, in the M group, the health status of the ovarian cells significantly worsened, as indicated by a decreased proliferating cell nuclear androgen (PCNA) signal and an increased TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling) signal (Fig

Gene Expr

Without efficient escape, released PROTACs may remain trapped within endosomal/lysosomal compartments, thereby limiting their access to cytosolic or nuclear targets and E3 ligases and ultimately attenuating degradation efficacy

In 2001, the Scientific Committee on Cosmetic Products stipulated that the total concentration of furocoumarins in cosmetics must not exceed 1 ppm (Kejlov et al., 2010)