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doi: 10.3389/fphar.2022.883251 Received 25 February 2022 Accepted 31 May 2022 Published 24 August 2022 Volume 13 - 2022 Edited by Iain Hargreaves, University of Liverpool, United Kingdom Reviewed by Guillermo Lopez Lluch, Universidad Pablo de Olavide, Spain Giuseppe Vita, University of Messina, Italy Updates Copyright 2022 Tsai, Hsu, Chang, Tseng and Chang

However, BDNF can prevent glutamate-induced excitotoxicity through pathways such as phosphatidylinositol 3-kinases (PI3K), phospholipase C- (PLC-), and ERK

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Moreover, it can lead to social isolation, as affected individuals may withdraw from social interactions to avoid potential embarrassment or negative reactions from others [9,19]