Low ROS levels activate cell survival signaling pathways, such as the unfolded protein response and Nrf2 pathways, whereas high ROS levels activate cell death signaling pathways, such as apoptosis and necroptosis pathways 43
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Braga CA, Follmer C, Palhano FL, Khattar E, Freitas MS, Romao L, Di Giovanni S, Lashuel HA, Silva JL, Foguel D (2011) The anti-Parkinsonian drug selegiline delays the nucleation phase of alpha-synuclein aggregation leading to the formation of nontoxic species

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