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This study represents the first large-scale application of perfusion culture for the production of RBD antigens

doi: 10.1038/89759 58 SamuelsJSHollandLLpezMMeyersKCumbieWGMcClainAet al

the prolonged exposure carries risks ranging from infection due to immune dysfunction in the days to weeks after an exposure to an increased risk of cancer to a longer-term effect such as atherosclerosis in later years