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In certain part of the world, there are areas called Blue Zones , where people have low rates of disease and live longer than anywhere else, their common lifestyles indicating how they achieve this longevity and why theyre able to avoid the chronic diseases increasingly prevalent in old age

doi: 10.1109/TBME.2015.2496264

Accordingly, the circadian oscillators have been reported to prevent the synchronous activation of the different components of the immune system, by temporally limiting various aspects of the innate immunity, as well as the expression of inflammatory genes and the trafficking of innate immune cells to sites of inflammation, to specific phases of the circadian cycle (as comprehensively reviewed by Man et al 54